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Lung Development, Injury and Repair (GRS)

Gordon Research Seminar

Applying Fundamental Principles of Lung Biology to Respiratory Health

November 6 - 7, 2021

Chairs Semil P. Choksi and Chimwemwe Mwase

Waterville Valley

56 Packard's Road

Waterville Valley, NH, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Lung Development, Injury and Repair is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting-edge ideas.

Respiration involves a complex interplay of the airway epithelium, alveoli, vasculature and underlying mesenchyme. Lung diseases such as COPD, asthma and pulmonary fibrosis, and pathogens compromise respiration, resulting in a global health and economic burden. This conference aims to highlight in vitro, in vivo, and clinical studies in lung biology and how this knowledge is being translated into the development of new drugs or therapeutic strategies for the treatment of lung disease. In particular, it will provide a platform for trainees in the lung biology field to present cutting-edge research in the areas of lung development, disease and therapeutics. In addition to the scientific sessions, this meeting will offer trainees opportunities to network with peers and will include a mentorship panel to explore career options both within and outside of academia.

Related Meeting

This GRS will be held in conjunction with the "Lung Development, Injury and Repair" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Unraveling the Mysteries of Lung Biology Discussion Leader: Franck Kamga Gninzeko (Virginia Commonwealth University, USA)
3:45 pm - 4:20 pm	Xin Sun (University of California, San Diego, USA) "Why Lung? What this Beautiful Organ Has Taught Us from Gas Exchange to Interoception"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Basic Principles of Lung Development and Function Discussion Leader: Terren Niethamer (University of Pennsylvania, USA)
7:30 pm - 7:45 pm	Elizabeth Corteselli (University of Vermont, USA) "Increases in Glutathione Dependent Protein Oxidation Impair Airway Basal Cell Differentiation"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Ahmad Nabhan (Genentech, USA) "Sculpting Regeneration with Cell-Specific Wnt Agonists"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Xin Wang (Brigham and Women's Hospital / Harvard Medical School, USA) "Basal Cell Adhesion Molecule Marks a Nasal Airway Epithelial Stem Cell Population that Is Increased in Patients with Chronic Rhinosinusitis with Nasal Polyps"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Claire Burgess (Boston University, USA) "Generation of Human Alveolar Epithelial Type I Cells from Pluripotent Stem Cells"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Jason Gokey (Vanderbilt University Medical Center, USA) "YAP Regulates Alveolar Epithelial Cell Differentiation and AGER via NFIB/KLF5/NKX2-1"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Matthew Riccetti (Cincinnati Children's Hospital Medical Center, USA) "Maladaptive Functional Changes in Alveolar Fibroblasts due to Perinatal Hyperoxia Impair Epithelial Differentiation"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Identifying Causes of Lung Disease and Therapeutic Strategies Discussion Leader: Jaymin Kathiriya (University of California, San Francisco, USA)
9:00 am - 9:15 am	Daniel Abebayehu (University of Virginia, USA) "Myeloid-Derived IL-1 Signaling Induces Unique Immuno-Fibroblast Subpopulations Critical for Pulmonary Fibrosis"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	Terren Niethamer (University of Pennsylvania, USA) "Pulmonary Endothelial Cell Expression of ATF3 Plays a Critical Role in Lung Regeneration"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Franck Kamga Gninzeko (Virginia Commonwealth University, USA) "Mechanical Ventilator Induced Senescence and DNA Damage in an Aging Model of Acute Lung Injury"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	Grace Bingham (University of Virginia, USA) "Comparative Analysis of Fibrosis and Immune Signatures in Patients with Long-Haul COVID and Idiopathic Pulmonary Fibrosis"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	Dawn Bravo (Stanford School of Medicine, USA) "Pre-Clinical Development of an Autologous Gene Corrected Stem Cell Therapy to Treat Cystic Fibrosis in the Upper Airways"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	Sriram Vaidyanathan (Stanford University, USA) "Fibrinogen Based Scaffolds Support the Transplantation of Gene Edited Upper Airway Basal Stem Cells in Immunocompromised Mice"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Exploring Careers in Lung Biology Discussion Leader: Anne-Karina Perl (Cincinnati Children's Hospital Medical Center, USA)
1:30 pm - 2:30 pm	Panel Discussion Careers in Lung Biology Laura Crotty Alexander (University of California, San Diego / VA San Diego Healthcare System, USA) Rory Morty (University Hospital Heidelberg, Germany) Daniel Tschumperlin (Mayo Clinic, USA)
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Conference ID: 15653

Contributors

University of California, San Francisco - Department of Biochemistry and Biophysics

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL157961. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.