Sunday
|
4:00 pm - 8:00 pm |
Arrival and Check-in
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Connecting DNA Repair with DNA Replication
Discussion Leader: Maria Jasin (Memorial Sloan Kettering Cancer Center, USA)
|
7:40 pm - 8:25 pm |
Karlene Cimprich (Stanford University School of Medicine, USA)
"The Causes and Consequences of Replication Stress"
|
8:25 pm - 8:35 pm |
Discussion
|
8:35 pm - 9:20 pm |
Johannes Walter (Harvard Medical School, USA)
"Transcription-Coupled DNA Repair in a Test Tube"
|
9:20 pm - 9:30 pm |
Discussion
|
Monday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Repair of Chromosomal Breaks
Discussion Leader: Zhenkun Lou (Mayo Clinic, USA)
|
9:00 am - 9:20 am |
Maria Jasin (Memorial Sloan Kettering Cancer Center, USA)
"Protecting Genome By Homologous Recombination"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Daniel Durocher (Lunenfeld-Tanenbaum Research Institute, Canada)
"CIP2A and the Spillover of DNA Lesions in Mitosis"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Sarah Hengel (University of Pittsburgh , USA)
"RAD51 Paralog Containing Complex SWSAP1-SWS1 Stimulates D-Loop Formation with Physiologically Relevant Substrate RPA Coated ssDNA"
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Upasana Roy (Columbia University, USA)
"Single-Molecule Studies Reveal a Chaperone-Like Behavior of the Rad51 Paralog Complex Rad55-Rad57"
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Alan D'Andrea (Dana-Farber Cancer Institute, USA)
"Assembly and Disassembly of the Shieldin Complex"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Binghui Shen (City of Hope, USA)
"Error-Prone, Stress-Induced 3’ Flap-Based Okazaki Fragment Maturation Supports Cell Survival"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Jian Ouyang (Massachusetts General Hospital, USA)
"RNA Transcripts Stimulate Homologous Recombination by Forming DR-Loops"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Yuan He (Northwestern University, USA)
"Structural Basis of Double Strand DNA Break Repair in NHEJ"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Patricia Opresko (University of Pittsburgh, USA) and Joann Sweasy (University of Arizona Cancer Center, USA)
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Base Excision Repair
Session in memory of Sam Wilson.
Discussion Leader: Yuan Liu (Florida International University, USA)
|
7:30 pm - 7:50 pm |
Joann Sweasy (University of Arizona Cancer Center, USA)
"Mechanisms of Base Excision Repair"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Bret Freudenthal (University of Kansas Medical Center, USA)
"Architecture and Mechanism of BER Complexes"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:45 pm |
Bennett Van Houten (University of Pittsburgh, USA)
"UV-DDB Functions to Stimulate Multiple DNA Glycosylases During Base Excision Repair of a Wide Variety of DNA Lesions: From Single-Molecules to Cells"
|
8:45 pm - 8:50 pm |
Discussion
|
8:50 pm - 9:05 pm |
Amy Whitaker (University of Kansas Medical Center, USA)
"Base Excision Repair of Oxidatively Damaged G-Quadruplex DNA"
|
9:05 pm - 9:10 pm |
Discussion
|
9:10 pm - 9:30 pm |
General Discussion
|
Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
DNA Replication and Replication Stress Response
Discussion Leader: Xiaohua Wu (The Scripps Research Institute, USA)
|
9:00 am - 9:20 am |
David Cortez (Vanderbilt University School of Medicine, USA)
"Mechanisms of Replication-Coupled DNA Repair"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:40 am |
Swati Balakrishnan (Vanderbilt University, USA)
"Progress Towards Determining the Structural Basis For Function of RADX"
|
9:40 am - 9:45 am |
Discussion
|
9:45 am - 9:55 am |
Andrew Elia (Massachusetts General Hospital, USA)
"RFWD3 in the Replication Stress Response"
|
9:55 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Evan Gates (LUMICKS, USA)
"Single-Molecule Investigation of DNA-Binding Proteins in Real Time"
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:45 am |
Coffee Break
|
10:45 am - 11:05 am |
Roger Greenberg (University of Pennsylvania, USA)
"How Cell Cycle Checkpoints Regulate DNA Damage Driven Inflammatory Signals"
|
11:05 am - 11:15 am |
Discussion
|
11:15 am - 11:35 am |
Alessandro Vindigni (Washington University School of Medicine, USA)
"Mechanisms of Replication Stress Response to Chemotherapeutics"
|
11:35 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Katelyn Hurley (South Dakota State University, USA)
"Poly-ADP-Ribosylation Modifies DNA-Protein Crosslinks to Signal For SPRTN-Dependent Degradation"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Houra Merrikh (Vanderbilt University, USA)
"Investigating the Mechanisms Behind R-Loop Induced Lethality upon Replication-Transcription Conflicts"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
General Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
DNA Repair and Human Diseases
Discussion Leader: Alessandro Vindigni (Washington University School of Medicine, USA)
|
7:30 pm - 7:50 pm |
Agata Smogorzewska (The Rockefeller University, USA)
"The Role of the Fanconi Anemia Pathway in Resolving Endogenous DNA Damage"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Kathleen Burns (Dana-Farber Cancer Institute, USA)
"Repairing Retrotransposition"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Reuben Harris (University of Minnesota, USA)
"APOBEC Mutagenesis in Mice and Humans"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Remi Buisson (University of California, Irvine, USA)
"Regulation of APOBEC3A Mutagenesis and Inflammation by the DNA Damage Response"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Lei Li (Zhejiang University, China)
"Transcription Reprogramming and Fanconi Anemia"
|
9:25 pm - 9:30 pm |
Discussion
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Genetics and Genomics of DNA Repair
Discussion Leader: Agnel Sfeir (Memorial Sloan Kettering Cancer Center, USA)
|
9:00 am - 9:20 am |
Shan Zha (Columbia University, USA)
"Expression Catalytic Inactive PARP1 in Mouse Is More Toxic than Loss of Both PARP1 and PARP2"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Yuan Liu (Florida International University, USA)
"DNA Base Damage and Repair Interplay with Chromatin Structures to Modulate Trinucleotide Repeat Instability"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Arvind Panday (Harvard Medical School, USA)
"Genetic Interaction Between Brca1 and Fancm in Stalled Fork Repair"
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Bing Xia (Rutgers Cancer Institute of New Jersey, USA)
"BRCA2 Associates with MCM10 to Suppress PrimPol-Mediated Re-Priming and Single-Stranded DNA Gap Formation After DNA Damage"
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Simon Boulton (The Francis Crick Institute, United Kingdom)
"Targeting DNA Repair Vulnerabilities in Cancer"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Xiaohua Wu (The Scripps Research Institute, USA)
"PIF1 Helicase Plays an Important Role in Break-Induced Replication in Mammalian Cells"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Xiaofeng Su (Massachusetts Institute of Technology, USA)
"RAD21 Promotes Repair of Oncogenic Replication Stress-Induced Damage in Ewing Sarcoma "
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Cheng-Zhong Zhang (Dana Farber Cancer Institute, USA)
"Genomic Features of Short Sequence Insertions and Large Sequence Duplications Suggest a Common Origin from Replication of Broken DNA"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Opportunities for Therapeutic Intervention in Cancer
Discussion Leader: Roger Greenberg (University of Pennsylvania, USA)
|
7:30 pm - 7:50 pm |
Li Lan (Harvard Medical School, USA)
"The Role of Transcription-Coupled Homologous Recombination (TC-HR) in Tumor Growth and Drug Resistance"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Junjie Chen (The University of Texas MD Anderson Cancer Center, USA)
"Targeting DNA Damage Repair Pathways In Cancer Therapy"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:40 pm |
Carla Danussi (Constellation Pharmaceuticals, USA)
"Genome-Wide CRISPR Screen Reveals Therapeutic Vulnerabilities in Cisplatin Resistant Bladder Cancer"
|
8:40 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Ramona Haji Seyed Javadi (Emory University, USA)
"Synthetic Lethal Screen Identifies Novel Players in DNA Damage Response that Confer Etoposide-Hypersensitivity in Small Cell Lung Cancer"
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Swarna Beesetti (St. Jude Children's Research Hospital, USA)
"FANCD2 Protects the Mitochondrial Genome from Oxidative DNA Damage"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Mark Hedglin (The Pennsylvania State University, USA)
"Dissecting the Interplay Between Human DNA Damage Tolerance Pathways"
|
9:25 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
DNA Repair and Therapeutic Responses
Discussion Leader: Junjie Chen (The University of Texas MD Anderson Cancer Center, USA)
|
9:00 am - 9:20 am |
Guo-Min Li (Univ of Texas Southwestern Med Center, USA)
"Mechanism by Which Mismatch Repair Deficiency Benefits Immunotherapy"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Alberto Ciccia (Columbia University Irving Medical Center, USA)
"Functional Interrogation of DNA Damage Response Variants with Base Editing Screens"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Joshua Heyza (Michigan State University, USA)
"Chromatin Association Dynamics of DDR Factors Revealed by Live-Cell Single-Molecule Imaging"
|
10:10 am - 10:15 am |
Discussion
|
10:15 am - 10:25 am |
Lianglin Zhang (Pfizer Inc, USA)
"Talazoparib-Focused Functional Genomic Approach Toward Novel Sensitizing Targets in BRCA-Proficient Tumors"
|
10:25 am - 10:30 am |
Discussion
|
10:30 am - 11:00 am |
Coffee Break
|
11:00 am - 11:20 am |
Zhenkun Lou (Mayo Clinic, USA)
"Regulation of DSB Repair Choice by a New Nuclease"
|
11:20 am - 11:30 am |
Discussion
|
11:30 am - 11:50 am |
Christopher Bakkenist (University of Pittsburgh, USA)
"Targeting ATM Deficiency in Cancer Therapy"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Robert Sobol (Mitchell Cancer Institute, USA)
"Temporal Dynamics of Base Excision/Single-Strand Break Repair Protein Complex Assembly and Disassembly Are Modulated by the PARP1/PARP2/NAD+/SIRT6 Axis"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Elise Fouquerel (Sidney Kimmel Medical College, Thomas Jefferson University, USA)
"PARP1 and PARP2 Prevent Oxidative Stress-Mediated Telomere Crisis Through Distinct Pathways"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Telomeres Maintenance and Genomic Instability
Discussion Leader: Shan Zha (Columbia University, USA)
|
7:30 pm - 7:50 pm |
Jan Karlseder (Salk Institute for Biological Studies, USA)
"A Telomere-Mitochondria Axis Regulates Inflammation in Replicative Crisis"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Agnel Sfeir (Memorial Sloan Kettering Cancer Center, USA)
"Nuclear Sensing of Mitochondrial DNA Breaks Enhances Immune Surveillance"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:40 pm |
Weihang Chai (Loyola University Chicago Stritch School of Medicine, USA)
"Crosstalk Between CST, RPA, RAD51 and BRCA2 at Stalled Forks"
|
8:40 pm - 8:45 pm |
Discussion
|
8:45 pm - 8:55 pm |
Ryan Barnes (University of Pittsburgh, USA)
"Telomeric 8-Oxoguanine Drives Premature Senescence Independently of Telomere Shortening "
|
8:55 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Zhiyuan Shen (Rutgers Cancer Institute of New Jersey, USA)
"Critical Roles of a Lysine Methylation in the C-Terminal SAP Domain of KU70 in Its Functions"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:30 pm |
General Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|